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The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

This adverse effect has not yet been clinically reported Hypopigmented patches, especially on sun-exposed areas have been observed after 1012 doses of intravenous injection by practitioners (unpublished observations)

For advanced type 2 diabetes with significant beta cell failure, or for type 1 diabetes, Tresiba (or another insulin) is essential and often superior to or required in addition to GLP-1 therapy

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Ostergaard et al , 2004)