The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+
DSIP is a peptide, and peptides are typically degraded by the stomach and intestines before entering the bloodstream
These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals
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Its one of the most common questions we get from labs and independent researchers alike