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ROS-mediated oxidative stress in asthma Enhanced ROS in the asthma pathogenesis is mainly contributed through the exposure to the environmental triggers including noxious gases, ozone, cigarette smoke, and also by activation of various inflammatory and phagocytic cells including eosinophils, monocytes, macrophages, and neutrophils when stimulated by the exogenous irritants (Henricks and Nijkamp 2001)