J Endocrinol (2011) 209(2):20310.10.1530/JOE-11-0015 10 MaXMengJJiaMBiLZhouYWangYet alExendin-4, a glucagon-like peptide-1 receptor agonist, prevents osteopenia by promoting bone formation and suppressing bone resorption in aged ovariectomized rats
Instead of being bound to resin, the non-side-chain carboxyl functionality of the amino acid in the peptide fragment is protected as a bulky ester
Several decades later, researchers noticed that the effects of GLP-1 are markedly reduced in people with Type 2 diabetes
La innovacin en los medicamentos basados en GLP-1 avanza en dos frentes simultneos: por un lado, el desarrollo de nuevas molculas, como multiagonistas que actan sobre los receptores de GLP-1, GIP y glucagn
Wang T, Hong JL, Gower EW, et al
PubMed laboratory research record [PMID: 29241711] PubMed record related to this compound for laboratory literature review