The effect of DSePA administration on RP was studied by subjecting mice to thoracic irradiation (X- or -rays, 18 Gy), treating them with DSePA (2.5 mg/kg body weight for three time a week for 6 months beginning on the day of irradiation) during the post-irradiation period and monitoring the incidence of RP through immunohistochemical and CT analysis (Table 2) [61, 62]
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We also excluded case reports ( n = 97), study protocols, systematic reviews and meta-analysis ( n = 28)
Possible side effects are not well defined because no controlled human safety trial exists
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