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doi: 10.3389/fendo.2021.661160 216 KalraSAggarwalSKhandelwalD

Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines

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Importantly, both that study and the present work focused on molecular responses elicited by additional stressors applied after PTSD-like pathology had been induced, rather than on baseline alterations, highlighting a shared emphasis on BDNF responses during re-exposure to stress

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