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Understanding why GLP-1 medications make you feel cold, when this is normal, and when to seek medical advice can help you manage this symptom effectively whilst continuing beneficial treatment for type 2 diabetes or weight management

This is perhaps the most important unknown in the entire field

In females, L2-Cmu mAb treatment led to a slight, albeit significant reduction in red blood cells (RBCs), hemoglobin (Hb), hematocrit (Hct), white blood cells (WBCs), lymphocytes (Supplementary Table 2), and serum phosphorus (Supplementary Table 3), though most values, with the exception of WBCs, remained within the normal range, and were less severely affected than previously reported with Ganitumab in young CD1 mice 26

A statistical technique called inverse probability weighting was used to remove the influence of other factors, such as patient age, sex, socioeconomic status, time since diabetes diagnosis, other conditions, and drug use

DOI: 10.1056/NEJMoa2206038