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The safety and pharmacology data behind this profile isnt thin six controlled trials covering roughly 900 participants, compiled in Stier et al
Clinical trial data from the STEP program showed that semaglutide 2.4mg weekly produced average weight loss of 14.9% of body weight over 68 weeks, compared to tirzepatide at 15mg which achieved approximately 22.5% in the SURMOUNT trials
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While GLP-1 medications have also had success in curbing addiction cravings in some patients, Breit says researchers are cautious to not oversimplify the cognitive effects of these medications
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