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Gastrointestinal symptoms are the most common side effects, particularly nausea, vomiting, and diarrhea
The retatrutide hair loss concerns can also be exacerbated by dehydration and nutritional deficits during aggressive weight loss phases
Elevated insulin levels can exacerbate inflammation and pain symptoms
The most common issues include: Nausea or reduced appetite that becomes too much Reflux/heartburn Constipation Diarrhea in some patients Fatigue, especially early on or with inadequate protein intake How we manage this clinically (what tends to work): Slow escalation rather than pushing through side effects Nutrition structure: prioritizing protein earlier in the day, avoiding large high-fat meals Hydration targets and constipation prevention strategies from week one Adjusting dose timing if symptoms cluster around certain days What we avoid: treating persistent symptoms as normal without adjusting the plan
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