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Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans
Phase 2a MASLD trial (48 weeks, liver disease population) In participants with metabolic dysfunction-associated steatotic liver disease (formerly NAFLD/NASH), retatrutide demonstrated remarkable liver fat reduction
Testosterone replacement therapy (TRT) can reduce sperm production and temporarily impact fertility in some men, making it important to discuss family planning goals with a healthcare provider before starting treatment
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