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When GLP-1 binds to these receptors, it directly influences their function: Macrophages: GLP-1s can shift macrophages from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, reducing inflammation in tissues like fat
Raghu G, et al
Endothelium dysfunction is characterized by impaired endothelial cell-dependent vasodilation, inflammation, apoptosis, and cell proliferation
While it is still in clinical development, trial data provides insights into how its typically studied
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