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Continuous, non-pulsatile GH elevation is actually a problem: sustained receptor activation leads to desensitization and blunted response

Avoid hydroquinone and steroid-based creams as they usually cause rebound hyperpigmentation

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These are all solvable sometimes with a dose adjustment, sometimes by looking at other factors but theyre best handled with medical guidance

They emphasize the importance of personalized medicine, acknowledging that while this combination may offer substantial benefits for some individuals, it may not be suitable for everyone

Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study