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If gastrointestinal symptoms are severe or persistent, delaying dose escalation or temporarily reducing the dose may be appropriate, as guided by the prescribing healthcare provider

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Caloric excess and obesity, driven by unhealthy lifestyles including poor dietary patterns, physical inactivity, current smoking, and heavy drinking, trigger lipid metabolism imbalances that disrupt systemic energy homeostasis [9]

The catalytic antioxidant proteins include the superoxide dismutases (SOD), catalase, the peroxiredoxins (Prx), and the glutathione peroxidases (GPx)

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