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While semaglutide is powerful, continuous use over many years without reevaluation might not be suitable for everyone

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Common criteria include: type 2 diabetes diagnosis with inadequate control on other medications, or BMI 27 kg/m with weight-related comorbidities (hypertension, sleep apnea, cardiovascular disease)

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Patients should discuss the duration of their supplementation with a healthcare provider to balance short-term energy benefits against long-term cardiovascular risks