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This narrowing of the spinal canal puts pressure on the nerve endings that form the sciatic nerve

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doi:10.1007/s40268-015-0119-3 8 Pandey RA

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Downstream transcription factors showed dramatic upregulation: c-Fos by 4.99-fold, c-Jun by 7.05-fold, and Egr-1 by 3.70-fold