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Weight gain is caused in part by fluid retention, and may also result from PPAR-gamma activation that results in increased adipose tissue mass, and a central effect to increase feeding (McCulloch, 2015) Notes: these drugs are also euglycemics Black Box Warning: CONGESTIVE HEART FAILURE HEART FAILURE: Thiazolidinediones, including rosiglitazone cause or exacerbate CHF in some patients
Egg quality, inflammation, immune signaling, and progesterone production dont show up clearly on standard labs
Ozempic butt The Cleveland Clinic notes that while Ozempic butt is a popular social media term that describes sagging or loose skin on the buttocks from rapid weight loss, its not an official medical diagnosis
(NEJM 2023) reported 24.2% body-weight reduction at 48 weeks on retatrutide 12 mg [5]
Median BMI was 39.4 kg/m, and 86% had diabetes
The archetype you are in at year minus one is largely the archetype you are defending at LOE
