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Topiramate can increase blood acid levels, potentially leading to kidney stones, weakened bones, and harm to unborn children
It does this by: Stimulating your pancreas to release insulin (which lowers blood sugar) Slowing down how fast your stomach empties (so you feel full longer) Reducing the release of another hormone called glucagon (which raises blood sugar) Acting on the brain to decrease appetite In people with type 2 diabetes or metabolic challenges, the body either doesnt make enough GLP-1 or doesnt respond to it properly
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These reactions were generally mild to moderate in severity