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However, post-marketing surveillance and patient reports suggest that some individuals taking semaglutide do experience leg cramps during treatment

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A comprehensive analysis published in JAMA Internal Medicine confirmed these findings in real-world clinical settings, showing that tirzepatide consistently outperformed semaglutide for weight loss across different patient populations

Findings from STEP Trials A phase 3 randomized clinical trial found that Semaglutide led to an average weight loss of 12.5%

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When growth hormone levels rise, the liver and many tissues begin to produce IGF-1, a signaling protein (growth factor) that triggers cellular repair processes