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Moreover, TB-500 also appeared to have promoted the expression of CD31, -smooth muscle actin (-SMA), Ang2, tie2, VEGFA, N1ICD, and p-p65 in the muscle tissues of murine CLI models

10.1007/BF00873919 Invest New Drugs 141 MurataJ

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Side effects are uncommon and mild, usually limited to minor warmth or redness at the injection site

In fact, the normal GSH/GSSG ratios of 100:1 will favor the reductive and conjugating activities of glutathione, whereas decreases in this ratio due to oxidative stress will impair these activities potentially enhancing the availability of drugs and AX ( The interaction of thiol-containing drugs and -lactam antibiotics has been also studied in vivo