GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects
But NAD+ levels decline with age
Vitamin E (800 IU daily) may benefit non-diabetic patients with biopsy-proven MASH, though long-term safety concerns exist regarding potential increased risks of hemorrhagic stroke and prostate cancer
It is known that ethanol consumption upregulates many of the genes involved in ethanol metabolism, and since GLP-1R agonism reduced ethanol consumption, it was expected that GLP-1R agonism would indirectly reduce expression of these genes 13
Lower visceral fat, blood pressure, blood lipids, and glycemic control all associate with fewer cardiovascular events in longer follow-up studies
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