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6 Extensive studies have demonstrated that PD patients with RBD (RBD-PD) exhibit more severe motor and nonmotor symptoms, including pronounced autonomic dysfunction, earlier cognitive deterioration, and accelerated motor progression

Administration of high-fat diet promotes the production of ROS, along with the elevation of tumor necrosis factor-alpha (TNF-) and adipokine secretion, thereby resulting in chronic inflammation [41]

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The model was characterized by immunocytochemistry and permeability for marker molecules