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If digestive disease is suspected, doctors may recommend further work-up and, when appropriate, procedures such as endoscopy to assess the upper digestive tract

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Similarly, if cold hands and feet develop suddenly after starting Mounjaro and are associated with other concerning symptoms such as severe fatigue, unexplained weight loss beyond expected therapeutic effect, or signs of thyroid dysfunction (such as hair loss, dry skin, or persistent fatigue), further investigation is warranted

It draws in extra fluid volume and releases extra hormones

Following 30 min fixation in 4 % paraformaldehyde, they were washed with PBS, and then permeabilized with 0.5 % Triton X-100 in PBS

Early clinical research suggests Retatrutide may promote greater fat-mass reduction while preserving lean body mass, which supports healthier body recomposition