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This creates a unique metabolic dance that the body needs time to adjust to, which is why the retatrutide dose schedule uses a gradual titration over many weeks
But the comparison is not entirely fair
The GC-MS system consisted of GCMS QP2010Plus gas chromatograph/mass spectrometer coupled with an AOC20S autosampler and an AOC20i auto injector (Shimadzu, Kyoto, Japan)
Typical schedule is weekly for the first month, then every 24 weeks based on how you respond and your B12 levels
While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
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