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Figure 2 The various aforementioned GLP-1RAs are peptides that are easily hydrolyzed by proteases, thus making their oral use basically ineffective

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The peptide's apparent stability across the gastric environment is part of why oral administration is sometimes argued for in this indication

For instance, in carotid endarterectomy procedures for diabetic patients, preoperative administration of GLP-1 RAs has been demonstrated to markedly enhance the expression of proteins that improve inflammatory pathways in diabetic atherosclerotic lesions, thereby promoting plaque stabilization [106]

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