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I269T (a common missense variant of NPT1) mutations increase the maximum volume by increasing the turnover rate of the urate transport and output tomitigate gouty risk, but do not change NPT1 membrane expressions (Sakiyama et al., 2016)

however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(/) mice

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Moreover, as L-carnitine is a non-essential nutrient, the National Health & Medical Research Council has also not considered a dietary reference intake for the nutrient