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Daily water intake must be forcibly increased to more than 2.5 liters

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Steed H, Walsh S, Reynolds N

New Safety Signal: Dysesthesia The TRIUMPH-4 trial identified a previously unreported side effect called dysesthesia an abnormal sensation of touch where normal sensations feel unusual, uncomfortable, or mildly painful (like tingling, numbness, or "pins and needles")

Fibre is fermented by gut bacteria into short-chain fatty acids, which activate other receptors (FFAR2 and FFAR3) that also trigger GLP-1 release

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