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Peripherally acting anti-obesity medicines with evidence for use in older adults Orlistat Weight loss trials None of the XENDOS trial participants were older adults, and hence the results from this study may not be applicable to an ageing population, although as the drug works peripherally there is no reason to suggest reduced efficacy or safety in elderly patients

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In addition, as with any emerging pharmacology, careful and continued analysis for potential adverse effects is required, especially as these therapies advance for treatments in genetically diverse patient populations