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The rats were randomly divided into 4 groups (each group of 20 rats): group A1 (normal control group under normoxia), group A2 (normal control group under normoxia, received low-dose l-carnitine at 50 mg/kg), group A3 (normal control group under normoxia, received high-dose l-carnitine at 100 mg/kg), group B (plateau model control group, received injecting normal saline), group C (low-dose l-carnitine intervention altitude model group, received 50 mg/kg l-carnitine) and group D (high-dose l-carnitine intervention altitude model group, received 100 mg/kg l-carnitine)

In some experiments, multiple doses of omega-3s were tested and showed a graded response (e.g., in cardiotoxicity and nephrotoxicity models), whereas in others, all doses provided similar benefits or only a single dose was evaluated

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EC 50 values at different concentrations of modulators were calculated and are plotted versus modulator concentrations for f , LSN3160440, and l , BETP