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To help replenish them, people may turn to natural sources like fruits and vegetables, supplements, or advanced methods like IV therapy
While side effects have not been reported, L-citrulline exerts a dose-dependent effect to activate arginase activity in a cell-based study (Douglass et al., 2023)
The same mechanism that slows gastric emptying to suppress appetite also creates the conditions for increased gas production
TintleSShemerASurez-FariasMFujitaHGilleaudeauPSullivan-WhalenMet alReversal of atopic dermatitis with narrow-band uvb phototherapy and biomarkers for therapeutic response
It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent
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