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doi: 10.1002/cpsc.13

Sikiric et al., 2018), and its role in the braingut and gutbrain axis (Sikiric et al., 2016), along with its CNS-disturbances therapy (Sikiric et al., 2016) and stress disorders (Sikiric et al., 2017

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Freeze-thaw cycling is damaging for the usual reasons, amplified here: the ice-water interface promotes both surface denaturation and dissociation, and a dimer that has come apart during freezing does not necessarily reassemble on thawing

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It was granted FDA Breakthrough Therapy Designation in January of this year based on some of their Phase 2b data (IMPACT)