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Upper and/or lower gastrointestinal adverse events with glucagon-like peptide-1 receptor agonists: incidence and consequences

Overall, tirzepatide treatment reduced systolic and diastolic BP by 4.8 and 1.7 mmHg, respectively.33 Tirzepatide appears to have a more significant impact on BP in Japanese individuals with T2DM.27, 28 At a dose of 15 mg, tirzepatide reduced systolic BP by 11.0 mmHg and diastolic BP by 5.6 mmHg from baseline.27 Further research is necessary to determine which factors of tirzepatide treatment are responsible for the more pronounced decrease in BP observed in Asian populations

Mitochondrial dysfunction and apoptotic signaling escalate hepatocyte loss, contributing to fibrosis and cirrhosis [36]

Jorsal, A

Month 2 (Weeks 5-8): 5.0 mg taken once weekly

2 STEP UP, 72-week study of adults with obesity using Wegovy (semaglutide 7.2mg)