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(PubMed) Calvani M, Benatti P, Mancinelli A, et al

But these are anecdotal observations, not clinical evidence, and they shouldnt be taken as a basis for changing treatment without medical guidance. Alcohol and other substance use disorders are common, but they remain substantially underdiagnosed and undertreated

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Until we have more data, some medical professionals recommended sticking with lower doses (0.4 to 1mg) of folate supplementation a day along with B12 for depression