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Taken together, these findings suggest that Nrf2 plays a vital role in mediating the chondroprotective effects of metformin by means of anti-oxidation, and that loss of Nrf2 substantially attenuates, but does not completely abolish, the therapeutic efficacy of metformin in the MIA-induced OA model
Chronic Conditions That Respond Well Certain chronic conditions appear particularly suited to the micro-dosing approach
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Ethics declarations Conflict of interest Sun-Ki Kim, Managing Editor of Food Science and Biotechnology , was not involved in the editorial consideration of this manuscript
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