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Wium-Andersen IK, Osler M, Jrgensen MB, Rungby J, Wium-Andersen MK
The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial (LEADER) led to a paradigm shift in the wider use of GLP-1RA from promising antihyperglycemic agents to cornerstone cardiometabolic therapies, demonstrating the significant reduction of major adverse cardiovascular events (MACE) with the use of liraglutide in the population with type 2 diabetes mellitus (T2DM) [12, 13]
Manufactured under strict quality standards and formulated with 0.9% benzyl alcohol as a preservative, this multi-dose solution is designed to maintain product stability and sterility during laboratory use
The body aches sometimes reported on tirzepatide and the anxiety some users experience do not appear to be more common on retatrutide, suggesting these effects are GLP-1/GIP mediated rather than glucagon-dependent
1 Here, we review the evidence regarding the benefits and adverse effects of GLP-1 receptor agonists, aiming to help guide primary care clinicians in using these agents while taking care of their patients who have type 2 diabetes mellitus or obesity