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Ensuring adequate hydration is therefore an important consideration with GLP-1 RA treatment, as is recommended by the label, particularly for people with renal impairment, as dehydration is known to be associated with renal dysfunction [98]

A fundamental cause for this challenge is the heterogeneity in the IBS-D population and therefore, the inability of finding the specific mechanism that is causing the symptoms that need to be targeted in individual patients

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However, because it may influence gut healing and inflammation, some researchers speculate it could indirectly support metabolic health