In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]
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Standard initial therapy for patients without neurological involvement is 1000 mcg intramuscularly (i.m.) three times a week for 2 weeks
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Vitamin C is well-known for its ability to enhance immune function by supporting the production of white blood cells and acting as an antioxidant
Also, attempts to use ex vivo gene therapy during machine perfusion (like delivering an Nrf2 gene or small interfering RNAs against pro-apoptotic factors into the kidney) are underway, which if successful could drastically reduce IR injury