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Moore LB, Goodwin B, Jones SA, et al., 2000

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Cancer Chemother Pharmacol 56 Suppl 1, 2126, 10.1007/s00280-005-0107-3 (2005)

Route Subcutaneous injection Schedule Weekly subcutaneous injections with gradual titration Injection Sites Rotate injection sites Dosing Dose Range: 210 mg weekly Use sterile technique when handling and administering Goal: Support significant weight reduction and metabolic improvements Frequency: Once weekly (use same day each week) Storage - Lyophilized: Store at 20 C or below in dry, dark conditions Storage - Reconstituted: Refrigerate at 28 C

Bitter taste receptors: Key target to understand the effects of polyphenols on glucose and body weight homeostasis