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In another study (86), RhGLP-1 significantly increased the density of surviving neurons, alleviated oxidative stress parameters, and promoted vascular proliferation when pretreated with only a single dose before performing permanent middle cerebral artery occlusion (pMCAO) in rats with diabetes

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Oxidative stress is implicated in the pathogenesis of SLE through multiple mechanisms, including mitochondrial dysfunction, activation of the type I IFN pathway, and the generation of oxidative DNA damage [130]

doi: 10.5498/wjp.v14.i3.445 29 ChoiSHGonenADiehlCJKimJAlmazanFWitztumJLet al

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But in MCAS , mast cells are ultra-sensitive and relentless, firing too often and causing a wide variety of symptoms: Common MCAS Symptoms: Skin: flushing, hives, itching, swelling Digestive: bloating, nausea, constipation or diarrhea, food reactions Brain/Nervous System: brain fog, fatigue, anxiety, dizziness Heart/Blood Pressure: rapid heartbeat, lightheadedness Lungs/Airways: tightness, wheezing General: trouble sleeping, temperature sensitivity, feeling wired but tired Musculoskeletal: widespread pain, burning sensations Some patients experience reactions approaching anaphylaxis intensity