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Therefore, future research should prioritize validating the feasibility of interfering with tumor-mediated neutrophil reprogramming, and investigate whether strategies such as targeted drug therapies, immune induction training, and gene editing, can prevent the development of T3 neutrophils

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Ueda P, Svanstrm H, Sderling J, Pazzagli L, Wintzell V, Eliasson B, Hviid A, Pasternak B

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B vitamins decreased the number of M1 macrophages expressing the Ca1.2 channel and increased the number of M2 macrophages expressing the same channel, suggesting a role in M1/M2 transition post-PNI