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Samples were loaded on a nanoscale capillary reverse-phase C18 column by an HPLC system (Thermo Fisher Scientific Ultimate 3000) and eluted by a gradient (90 min)

Prolactin elevation was present but lower than that induced by thyrotropin-releasing hormone (TRH)

Osteoarthritis Cartilage 15 , 695700 (2007)

Currently, no long-term human studies exist , but BPC-157 has shown no signs of organ damage or hormonal suppression in months-long rodent studies

Berberine and other ingredients could accumulate to higher levels in people with reduced kidney function

Another safety trial registered in 2015 but cancelled the next year, again with nothing published.