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2011;111(2 Suppl 1):eS104

Once bound, many peptide-receptor complexes undergo endocytosis

Serious but rare adverse effects require particular attention: Pancreatitis : Patients should be counselled to seek immediate medical attention if they experience severe, persistent abdominal pain radiating to the back, as acute pancreatitis has been reported with GLP-1 receptor agonists

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However, dose increases should follow the FDA-recommended schedule of 2.5 mg increments every four weeks to minimize gastrointestinal adverse effects