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11 Mechanisms of Action and Need for Further Study The clinical benefits for both classes of drugs cannot be explained only by effects on glucose-lowering or other established risk factors, leading many to consider novel mechanisms of action
Crohns and Colitis 360 2023;5:18
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Eli Lilly and Company originally applied TZT to control blood glucose in 2016
This can lead to a gradual loss of bacteriostatic potency over time
Approval (2017) FDA News Release (March 8th, 2024): FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight FDA News Release (August 15th, 2025): FDA Approves Treatment for Serious Liver Disease Known as MASH OZEMPIC (semaglutide) injection, for subcutaneous use
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