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A Danish and Norwegian cohort study of over 424,000 patients found that semaglutide use more than doubled the risk of NAION compared to patients taking other diabetes medications

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In clinical trials , it produced an average weight loss of 13.6% over 64 weeks (about a year and three months)

Evidence and Clinical Guidance GLP-1 receptor agonists, primarily prescribed for type 2 diabetes and weight management, have demonstrated modest but consistent improvements in cholesterol and lipid profiles

For perspective, if you weigh 200 pounds, that's a difference between losing about 30 pounds on tirzepatide versus 16-17 pounds on semaglutide after a year of treatment