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First, the magnitude of weight loss approaching bariatric surgery results without surgery has shifted conversations about what pharmacotherapy can achieve

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Berman E, Heller G, Santorsa J, McKenzie S, Gee T, Kempin S, Gulati S, Andreeff M , Kolitz J, Gabrilove J, et al

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The prevalence of AN is increasing, largely as a result of the rise in obesity and T2DM, with obesity-associated AN being the most common phenotype [37]