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While there are significant discoveries and advancements in the study of drug combinations, there are still limitations in the experimental design of some studies

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Combining MDSC checkpoint blockade with immune checkpoint inhibitors (such as PD-1/PD-L1 blockade), adaptive cellular therapies (e.g., CAR-T and CAR-NK cells) and multiple MDSC checkpoints targeting strategies could create synergistic therapeutic strategies to enhance anti-tumor immunity while mitigating the negative impact of MDSCs

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This difference became even more pronounced when comparing TCC-treated wounds to control wounds on days 7, 14, and 21, where the TCC group consistently showed significantly smaller unhealed areas