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Phase 2a trial of GSBR-1290 (45mg and 90mg) in 54 T2DM patients over 12 weeks observed significant reduction in HbA1c (45 mg: -1.01%, p=0.008
The poisoning is primarily due to the neurotoxic compound 4-O-methylpyridoxine (MPN, also known as ginkgotoxin) which interferes with pyridoxine (vitamin B 6 ) metabolism, leading to serious neurological manifestations including neurotoxicity, seizures, and loss of consciousness (Wada et al., 1988
Chang J, Leong RW, Wasinger VC, Ip M, Yang M, Phan TG ~ J Med Food
Studies examine its potential roles in pigmentation enhancement, photoprotection, and sexual function modulation through melanocortin receptor activation in experimental settings
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