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These results are consistent with SURPASS2, a 40week, openlabel, phase 3 trial in a cohort of patients with metformintreated T2D in which onceweekly tirzepatide (5, 10, or 15 mg) was noninferior and superior to semaglutide 1 mg for HbA1c reduction and produced substantially greater, dosedependent weight loss
161,168 The most significant pharmacokinetic alterations were reported following the administration of a single 5 mg dose of tirzepatide, with the C max and AUC values of ethinylestradiol decreasing by 59% and 21%, respectively, and those of norelgestromin by 55% and 22%, respectively (Table 4)
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When NOT to Increase Your Tirzepatide Dose The four-week interval is a minimum, not a target
