The scientific limitations of transdermal delivery for large molecules make their marketing claims implausible, and no clinical evidence supports their effectiveness for weight loss
This is because it targets three pathways connected to metabolism and appetite: GLP-1 GIP Glucagon One of the main differentiators in the activity along the glucagon pathways
Petermann-Rocha F, Ferguson LD, Gray SR, Rodrguez-Gmez I, Sattar N, Siebert S, Ho FK, Pell JP, Celis-Morales C
For programmes costing 500, and 1000, an average additional weight loss of 2, and 3 kg, respectively, must be maintained for life
This rapid loss can accentuate the appearance of aging more sharply than a typical weightloss journey
Published research includes rat Achilles tendon transection studies documenting accelerated functional recovery and improved collagen organization at 4-8 weeks post-injury versus saline controls