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Expression of the GPX6 gene is is near exclusive to the gonads with much higher levels of expression in the testes that the ovaries

However, oral formulations are not without drawbacks

Cost: GLP-1 medications can be expensive, especially for patients who do not have insurance coverage or who have high copays or deductibles

A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol

10.1186/s43088-019-0021-0 6 AhmadF

I dont yet have a clean mechanistic explanation for why, but clinically Ive noticed it consistently enough that its changed how I approach this patient type