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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
Substantial weight reduction, regardless of the method, can lead to decreased bone mineral density, particularly at weight-bearing sites such as the hip and spine
PubMed CrossRef Gejl M, Gjedde A., Egefjord L., et al
Trump said it doesnt have to The Biden administration proposed a rule that would have required state Medicaid programs to cover GLP-1s for obesity treatment, but the Trump administration said it will leave the option up to the states (Scott Olson/Getty Images)
Ozempics manufacturer, Novo Nordisk, did not tell people that NAION-related blindness is a potential side effect, and affected patients are filing lawsuits about this
482 Patients who receive HD may be at risk of the development of carnitine deficiency as a result of loss of carnitine during the dialysis procedure, in addition to possible reductions in dietary intake and endogenous synthesis
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